A Review of the Relationship Between Type 2 Diabetes and Hepatitis C Virus Infection

Abstract

Background: Regardless of the cause, type 2 diabetes is a frequent consequence of total hepatic illnesses, particularly when they are progressive. Clinical and experimental findings do, however, point to an immediate involvement of HCV in the disruption of glucose metabolism.

Objective: This review aims to assess the connection among hepatitis C virus infection and T2DM (type 2 Diabetic Mellitus).

Material and methods: According to cross-sectional and longitudinal studies, insulin resistance (IR) and T2D are more likely to develop in people with chronic HCV infection.

Results: Although the evidence currently available should be seen as preliminary, it appears that this virus affects glucose metabolism via cellular mechanisms associated with host's innate immune response. Furthermore, epidemiological research has shown that people with T2D may also be more likely to have negative effects from their HCV infection. Both IR and T2D lessen the early and persistent virological response to in addition to hastening the histology as well as clinical development of chronic HCV.

Conclusion: IR and T2D have significant influence on the course of HCV and how well it responds to antivirals, which calls for targeted and efficient interventions to treat such metabolic abnormalities. Therefore, to enhance the therapeutic care of people with chronic HCV, a keen interpretation of the processes behind the glucose metabolic derangements associated with HCV is necessary.